| Sunday Sep. 12 |
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Arizona CardinalsNissan Stadium, Nashville, TN | 1:00pm ET CBS | L 38-13 |
| Sunday Sep. 19 |
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at Seattle SeahawksCenturyLink Field, Seattle, WA | 4:25pm ET CBS | W 33-30(OT) |
| Sunday Sep. 26 |
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Indianapolis ColtsNissan Stadium, Nashville, TN | 1:00pm ET CBS | Buy Tickets |
| Sunday Oct. 3 |
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at New York JetsMetLife Stadium, East Rutherford, NJ | 1:00pm ET CBS | Buy Tickets |
| Sunday Oct. 10 |
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at Jacksonville JaguarsTIAA Bank Field, Jacksonville, FL | 1:00pm ET CBS | Buy Tickets |
| Monday Oct. 18 |
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Buffalo BillsNissan Stadium, Nashville, TN | 8:15pm ET ESPN | Buy Tickets |
| Sunday Oct. 24 |
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Kansas City ChiefsNissan Stadium, Nashville, TN | 1:00pm ET CBS | Buy Tickets |
| Sunday Oct. 31 |
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at Indianapolis ColtsLucas Oil Stadium, Indianapolis, IN | 1:00pm ET CBS | Buy Tickets |
| Sunday Nov. 7 |
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at Los Angeles RamsSoFi Stadium, Inglewood, CA | 8:20pm ET NBC | Buy Tickets |
| Sunday Nov. 14 |
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New Orleans SaintsNissan Stadium, Nashville, TN | 1:00pm ET CBS | Buy Tickets |
| Sunday Nov. 21 |
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Houston TexansNissan Stadium, Nashville, TN | 1:00pm ET CBS | Buy Tickets |
| Sunday Nov. 28 |
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at New England PatriotsGillette Stadium, Foxborough, MA | 1:00pm ET CBS | Buy Tickets |
| Sunday Dec. 5 |
BYE | |||
| Sunday Dec. 12 |
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Jacksonville JaguarsNissan Stadium, Nashville, TN | 1:00pm ET CBS | Buy Tickets |
| Sunday Dec. 19 |
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at Pittsburgh SteelersHeinz Field, Pittsburgh, PA | 1:00pm ET CBS | Buy Tickets |
| Thursday Dec. 23 |
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San Francisco 49ersNissan Stadium, Nashville, TN | 8:20pm ET NFLN | Buy Tickets |
| Sunday Jan. 2 |
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Miami DolphinsNissan Stadium, Nashville, TN | 1:00pm ET CBS | Buy Tickets |
| Sunday Jan. 9 |
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at Houston TexansNRG Stadium, Houston, TX | 1:00pm ET CBS | Buy Tickets |
